Expression profiling suggests microglial impairment in human immunodeficiency virus neuropathogenesis.
Stephen D GinsbergMelissa J AlldredSatya M GunnamConsuelo SchiroliSang Han LeeSusan MorgelloTracy FischerPublished in: Annals of neurology (2018)
Our results support the notion that microglia contribute to the maintenance of brain homeostasis and their potential loss of function in the context of chronic inflammation contributes to neuropathogenesis. Furthermore, they indicate the utility of profiling MΦs/microglia to increase our understanding of microglia function, as well as to ascertain alterations in specific pathways, genes, and potentially, encoded proteins that may be amenable to targeted treatment modalities in diseases affecting the brain. Ann Neurol 2018;83:406-417.
Keyphrases
- human immunodeficiency virus
- inflammatory response
- neuropathic pain
- hepatitis c virus
- resting state
- antiretroviral therapy
- white matter
- genome wide
- lipopolysaccharide induced
- oxidative stress
- hiv infected
- lps induced
- functional connectivity
- cerebral ischemia
- spinal cord
- genome wide identification
- spinal cord injury
- hiv aids
- cancer therapy
- hiv positive
- risk assessment
- climate change
- brain injury
- blood brain barrier
- subarachnoid hemorrhage