Impact of Interaction between Single Nucleotide Polymorphism of XRCC1, XRCC2, XRCC3 with Tumor Suppressor Tp53 Gene Increases Risk of Breast Cancer: A Hospital Based Case-Control Study.

Kailas D DatkhileRashmi A GudurSuresh J BhosalePratik P DurgawaleNilam J JagdaleAshwini L MoreAnand K GudurSatish R Patil

Published in: Asian Pacific journal of cancer prevention : APJCP (2023)

The findings derived from our study concluded that the heterozygous variant Arg280His genotype of XRCC1 and Thr241Met polymorphism of XRCC3 in combination with heterozygous arginine72proline genotype and heterozygous Arg249Ser polymorphism of TP53 showed significant association with breast cancer risk in Maharashtrian women.

Keyphrases

dna repair
breast cancer risk
early onset
dna damage
nitric oxide
type diabetes
gene expression
pregnant women
copy number
tyrosine kinase
metabolic syndrome
dna methylation
skeletal muscle