Cage-like structures based on constrained cyclic arylopeptoids.

The access to cupola-like or tube-like structures from ortho - and meta -arylopeptoid macrocycles was explored through CuAAC reaction using a partially flexible bis(azide) and Cu I -N-heterocyclic carbene as catalyst. NMR studies showed that a bis-triazolium bicylic compound in the ortho -series adopts well-defined structure in polar aprotic and protic solvents. Besides, preliminary study revealed its potential for oxoanion recognition.