OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Oxidative stress in polycystic ovary syndrome.
Ewa RudnickaAnna Maria DuszewskaMarek KucharskiPaweł TyczyńskiRoman SmolarczykPublished in: Reproduction (Cambridge, England) (2022)
Oxidative stress (OS), an imbalance between oxidants and antioxidants in cells, is one of many factors playing essential roles in the pathogenesis of polycystic ovary syndrome (PCOS). PCOS is described mainly as a disproportion of reproductive hormones, leading to chronic anovulation and infertility in women. Interestingly, OS in PCOS may be associated with many disorders and diseases. This review focuses on characteristic markers of OS in PCOS and the relationship between OS and PCOS related to insulin resistance (IR), hyperandrogenemia, obesity, chronic inflammation, cardiovascular diseases, and cancer. Interestingly, in patients with PCOS, an increase in oxidative status and insufficient compensation of the increase in antioxidant status before any cardiovascular complications are observed. Moreover, free radicals promote carcinogenesis in PCOS patients. However, despite these data, it has not been established whether oxygen stress influences PCOS development or a secondary disorder resulting from hyperglycemia, IR, and cardiovascular and cancer complications in women.
Keyphrases
- polycystic ovary syndrome
- insulin resistance
- oxidative stress
- induced apoptosis
- adipose tissue
- metabolic syndrome
- skeletal muscle
- high fat diet
- diabetic rats
- high fat diet induced
- type diabetes
- dna damage
- papillary thyroid
- ischemia reperfusion injury
- end stage renal disease
- newly diagnosed
- ejection fraction
- squamous cell
- weight loss
- endoplasmic reticulum stress
- peritoneal dialysis
- machine learning
- chronic kidney disease
- prognostic factors
- deep learning
- patient reported outcomes
- stress induced
- patient reported