Login / Signup

Traversing Steric Limitations by Cooperative Lewis Base/Palladium Catalysis: An Enantioselective Synthesis of α-Branched Esters Using 2-Substituted Allyl Electrophiles.

Kevin J SchwarzColin M PearsonGabriel A Cintron-RosadoPeng LiuThomas N Snaddon
Published in: Angewandte Chemie (International ed. in English) (2018)
Cooperative catalysis enables the direct enantioselective α-allylation of linear prochiral esters with 2-substituted allyl electrophiles. Critical to the successful development of the method was the recognition that metal-centered reactivity and the source of enantiocontrol are independent. This feature is unique to simultaneous catalysis events and permits logical tuning of the supporting ligands without compromising enantioselectivity.
Keyphrases
  • molecular docking
  • visible light
  • machine learning
  • deep learning