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Bleomycin induces senescence and repression of DNA repair via downregulation of Rad51.

Fuqiang ChenWenna ZhaoChenghong DuZihan ChenJie DuMeijuan Zhou
Published in: Molecular medicine (Cambridge, Mass.) (2024)
Our works suggest that the inhibition of Rad51 plays a pivotal role in bleomycin-induced AECs senescence and lung injury, offering potential strategies to alleviate the pulmonary toxicity of bleomycin.
Keyphrases
  • dna repair
  • dna damage
  • pulmonary fibrosis
  • oxidative stress
  • endothelial cells
  • dna damage response
  • diabetic rats
  • high glucose
  • pulmonary hypertension
  • cell proliferation
  • stress induced
  • signaling pathway
  • drug induced