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The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis.

Arun Kumar JaiswalSandeep TiwariSyed Babar JamalLetícia de Castro OliveiraLeandro Gomes AlvesVasco AzevedoPreetam GhoshCarlo Jose Freira OliveiraSiomar C Soares
Published in: BMC genomics (2020)
In summary, we identified four pathogenicity islands (PAIs), eight genomic islands (GIs) in subsp. pallidum, whereas subsp. endemicum has three PAIs and seven GIs and subsp. pertenue harbours three PAIs and eight GIs. Concerning the presence of genes in PAIs and GIs, we found some genes related to lipid and amino acid biosynthesis that were only present in the subsp. of T. pallidum, compared to T. pallidum subsp. endemicum and T. pallidum subsp. pertenue.
Keyphrases
  • genome wide
  • amino acid
  • gene expression
  • escherichia coli
  • dna methylation
  • copy number
  • pseudomonas aeruginosa
  • cystic fibrosis
  • hepatitis c virus
  • bioinformatics analysis
  • hiv infected
  • cell wall