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Association of proton pump inhibitor use with endothelial function and metabolites of the nitric oxide pathway: A cross-sectional study.

Michael NoldeMartin BahlsNele FriedrichMarcus DörrTobias DreischulteStefan B FelixIna-Maria Rückert-EhebergNayeon AhnUte AmannEdzard SchwedhelmHenry VölzkeMarkus M LerchJakob LinseisenChrista MeisingerSebastian E Baumeister
Published in: Pharmacotherapy (2021)
Our data provide evidence that long-term intake of PPIs might inhibit human DDAH activity, resulting in impaired endothelial NO production and reduced vascular function. In the long run, this might explain an increased risk for cardiovascular diseases associated with long-term PPI use.
Keyphrases
  • nitric oxide
  • endothelial cells
  • cardiovascular disease
  • ms ms
  • physical activity
  • electronic health record
  • risk factors
  • induced pluripotent stem cells
  • nitric oxide synthase
  • type diabetes
  • protein protein