Functional connectivity MRI provides an imaging correlate for chimeric antigen receptor T-cell-associated neurotoxicity.
Sophia StoeckleinStephan WunderlichBoris PapazovMichael WinkelmannWolfgang G KunzKatharina MuellerKatharina ErnstVeit M StoeckleinViktoria BlumenbergPhilipp KarschniaVeit L BückleinKai RejeskiChristian SchmidtMichael von Bergwelt-BaildonJoerg-Christian TonnJens RickeHesheng LiuJan RemiMarion SubkleweLouisa von BaumgartenFlorian SchoeberlPublished in: Neuro-oncology advances (2023)
RsfMRI-based DCI might be suitable to directly quantify the severity of ICANS in individual patients undergoing CAR T-transfusion. Besides ICANS, DCI seems a promising diagnostic tool to quantify functional brain network alterations during encephalopathies of different etiologies, in general.