Mathematical modeling of extracorporeal CO2 removal therapy : A validation carried out on ten pigs.
Simon HabranThomas DesaivePhilippe MorimontBernard LambermontPierre DaubyPublished in: Medical & biological engineering & computing (2017)
The extracorporeal CO2 removal device (ECCO2RD) is used in clinics to treat patients suffering from respiratory failures like acute respiratory distress syndrome (ARDS) or chronic obstructive pulmonary disease (COPD). The aim of this device is to decarboxylate blood externally with low blood flow. A mathematical model is proposed to describe protective ventilation, ARDS, and an extracorporeal CO2 removal therapy (ECCO2RT). The simulations are compared with experimental data carried out on ten pigs. The results show a good agreement between the mathematical simulations and the experimental data, which provides a nice validation of the model. This model is thus able to predict the decrease of PCO2 during ECCO2RT for different blood flows across the extracorporeal lung support.
Keyphrases
- acute respiratory distress syndrome
- mechanical ventilation
- chronic obstructive pulmonary disease
- extracorporeal membrane oxygenation
- blood flow
- end stage renal disease
- electronic health record
- newly diagnosed
- lung function
- molecular dynamics
- chronic kidney disease
- ejection fraction
- primary care
- peritoneal dialysis
- prognostic factors
- patient reported outcomes
- machine learning
- monte carlo
- mesenchymal stem cells
- deep learning
- bone marrow
- cell therapy
- data analysis