Macrophage Migration Inhibitory Factor Promotes Thromboinflammation and Predicts Fast Progression of Aortic Stenosis.
Karin Anne Lydia MuellerCarolin LangnauTobias HarmManuel SigleKristina MottMichal DroppaOliver BorstAnne-Katrin RohlfingSarah GekelerManina GünterNora GöbelUlrich F W FrankeMedhat RadwanChristian SchlensakHenrik JanningSophia ScheuermannChristian Martin SeitzDominik RathKlaus-Peter KreisselmeierTatsiana CastorIris Irmgard MuellerHarald SchulzeStella E AutenriethMeinrad Paul GawazPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our findings suggest a key role for platelet-derived MIF and its interplay with circulating and valve resident monocytes/macrophages in local and systemic thromboinflammation during accelerated AS. MIF-based biomarkers predict an accelerated course of AS and represent a novel pharmacological target to attenuate progression of AS.
Keyphrases
- aortic stenosis
- transcatheter aortic valve replacement
- aortic valve
- ejection fraction
- aortic valve replacement
- transcatheter aortic valve implantation
- left ventricular
- coronary artery disease
- adipose tissue
- patient safety
- dendritic cells
- quality improvement
- mitral valve
- heart failure
- immune response
- peripheral blood
- drug induced