Kallopterolides A-I, a New Subclass of seco -Diterpenes Isolated from the Southwestern Caribbean Sea Plume Antillogorgia kallos .

Kallopterolides A-I ( 1 - 9 ), a family of nine diterpenoids possessing either a cleaved pseudopterane or a severed cembrane skeleton, along with several known compounds were isolated from the Caribbean Sea plume Antillogorgia kallos . The structures and relative configurations of 1 - 9 were characterized by analysis of HR-MS, IR, UV, and NMR spectroscopic data in addition to computational methods and side-by-side comparisons with published NMR data of related congeners. An investigation was conducted as to the potential of the kallopterolides as plausible in vitro anti-inflammatory, antiprotozoal, and antituberculosis agents.