Loss of ASD-Related Molecule Caspr2 Affects Colonic Motility in Mice.
Beatriz G RobinsonBeau A OsterKeiramarie RobertsonJulia A KaltschmidtPublished in: bioRxiv : the preprint server for biology (2023)
Autism spectrum disorder (ASD) patients experience sensory abnormalities and chronic gastrointestinal (GI) problems. We ask if the ASD-related synaptic cell-adhesion molecule Caspr2, associated with ASD-related hypersensitivity in the central and peripheral nervous system, is present and/or plays a role in GI function in mice. Results show Caspr2 is present in enteric sensory neurons; lack of Caspr2 alters GI motility, suggesting enteric sensory dysfunction may contribute to ASD-related GI symptoms.
Keyphrases
- autism spectrum disorder
- attention deficit hyperactivity disorder
- intellectual disability
- mental health
- cell adhesion
- ejection fraction
- high fat diet induced
- prognostic factors
- drug induced
- escherichia coli
- spinal cord injury
- physical activity
- depressive symptoms
- skeletal muscle
- patient reported
- pseudomonas aeruginosa