Evaluating blood-brain barrier permeability in a rat model of type 2 diabetes.

Ju QiaoChristopher M LawsonKilian F G RentrupPraveen KulkarniCraig F Ferris

Published in: Journal of translational medicine (2020)

Small vessel disease as assessed by permeability in the blood-brain barrier in type 2 diabetes is pervasive and includes much of the brain. The increase in blood-brain barrier permeability is a likely contributing factor to diabetic encephalopathy and dementia.

Keyphrases

blood brain barrier
type diabetes
cerebral ischemia
endothelial cells
glycemic control
mild cognitive impairment
cardiovascular disease
insulin resistance
early onset
white matter
cognitive impairment
skeletal muscle
adipose tissue
weight loss
brain injury