Investigating Vitamin D-Binding Protein's Role in Childhood Health and Development.
Charlotte DelrueSpeeckaert ReinhartJoris Richard DelangheAgnieszka PrytułaMarijn M SpeeckaertPublished in: International journal of molecular sciences (2024)
Vitamin D-binding protein (DBP), also known as Gc-globulin, is a protein that affects several physiological processes, including the transport and regulation of vitamin D metabolites. Genetic polymorphisms in the DBP gene have a significant impact on vitamin D levels and may have implications for disease risk. DBP polymorphisms are linked to differential immune responses, which could influence the onset of juvenile diseases. This narrative review examines the various roles of DBP, with a focus on bone health, immunological regulation, and lipid metabolism in children. Chronic disorders affected by DBP polymorphisms include bone abnormalities, autoimmune diseases, cardiovascular issues, childhood asthma, allergies, cystic fibrosis, acute liver failure, celiac disease, inflammatory bowel disease, and chronic kidney disease. Future research should focus on identifying the processes that underpin the many roles that DBP plays and developing customized therapeutics to improve health outcomes in the juvenile population.
Keyphrases
- liver failure
- binding protein
- chronic kidney disease
- cystic fibrosis
- healthcare
- public health
- celiac disease
- immune response
- hepatitis b virus
- mental health
- bone mineral density
- lung function
- young adults
- chronic obstructive pulmonary disease
- health information
- small molecule
- early life
- genome wide
- end stage renal disease
- copy number
- dna methylation
- risk assessment
- pseudomonas aeruginosa
- bone loss
- body composition
- mass spectrometry
- human health
- health promotion
- bone regeneration
- childhood cancer
- inflammatory response
- respiratory failure
- protein protein
- gas chromatography