Synthesis of 6 H -Chromeno[4,3- b ]quinolin-7-ylphosphonates through Three Component Phosphonylation of Coumarin Carbaldehyde and Their Antimicrobial and Photophysical Properties.

Organophosphorylated coumarin derivatives were synthesized by a three-component reaction of 4-chloro-3-formylcoumarin, aromatic amines, and dialkyl phosphite in the presence of ZnCl 2 . This process includes the formation of C(sp 3 )-P and C(sp 2 )-N bonds in one pot. The modular scope of the reaction allowed rapid access to a variety of 6 H -chromeno[4,3- b ]quinolin-7-ylphosphonate derivatives in good yields. Furthermore, photophysical studies of the products revealed their stimulating fluorescence properties.