Difluoromethylcarbene for iron-catalyzed cyclopropanation.

Yaya DuanJin-Hong LinJi-Chang XiaoYu-Cheng Gu

Published in: Chemical communications (Cambridge, England) (2018)

Difluoroethylsulfonium salt, Ph2S+CH2CF2H OTf-, was developed into a convenient difluoromethylcarbene reagent for the iron-catalyzed cyclopropanation of terminal olefins, giving various difluoromethyl-cyclopropanes with excellent diastereoselectivities and in high yields.

Keyphrases

room temperature
iron deficiency
cystic fibrosis
ionic liquid