Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis.

Simin QiXiaoqing GuanJia ZhangDehua YuXuefei YuQinglin LiWenjuan YinXiang-Dong ChengWeidong ZhangJiang-Jiang Qin

Published in: Molecular cancer (2022)

These results indicated that inhibiting UbcH5c is a novel and effective strategy for treating pancreatic cancer and DHPO represents a new class of UbcH5c inhibitor and may be further developed as an anti-pancreatic cancer therapeutic agent.

Keyphrases

small molecule
signaling pathway
protein protein
cancer therapy