The T cell receptor repertoire and antigen specificities in small joints of early rheumatoid arthritis - diversity and clonality.
Sara TurcinovErik Af KlintBertrand Van SchoubroeckArlette KouwenhovenSohel MiaKarine CheminHans WilsCarl Van HoveAn De BondtKen KeustermansJeroen Van HoudtJoke ReumersNathan FelixNavin L RaoPieter PeetersFrederik StevenaertLars KlareskogMurray McKinnonDaniel BakerAnish SuriVivianne MalmströmPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Minimally invasive biopsies of the RA synovium allow for single cell TCR-sequencing and phenotyping. Clonally expanded viral-reactive T cells account for part of the diverse CD4+ T cell repertoire. TRBV20-1 bias in ACPA-positive patients suggests recognition of common antigens. This article is protected by copyright. All rights reserved.
Keyphrases
- rheumatoid arthritis
- single cell
- minimally invasive
- end stage renal disease
- ejection fraction
- high throughput
- newly diagnosed
- chronic kidney disease
- disease activity
- prognostic factors
- peritoneal dialysis
- interstitial lung disease
- dendritic cells
- ankylosing spondylitis
- regulatory t cells
- high throughput sequencing
- robot assisted
- systemic sclerosis
- patient reported
- idiopathic pulmonary fibrosis