In Vitro and In Vivo Drug-Response Profiling Using Patient-Derived High-Grade Glioma.
Robin G RajanVirneliz Fernandez-VegaJantzen SperryJonathan NakashimaLong H DoWarren AndrewsSimina BocaRezwanul IslamSajeel A ChowdharyJan SeldinGlauco R SouzaLouis ScampaviaKhalid A HanafyFrank D VrionisTimothy P SpicerPublished in: Cancers (2023)
Our integrative model utilizing molecular, in vitro, and in vivo approaches provides direct evidence of a patient's tumor response drifting with treatment and time, as demonstrated by dynamic changes in their tumor profile, which may affect how one would address that drift pharmacologically.