The pharmacokinetic parameters and the effect of a single and repeated doses of memantine on gastric myoelectric activity in experimental pigs.

Jan BuresJaroslav KvetinaVera RadochovaIlja TachecíEva PeterovaDavid HermanRafael DolezalMarcela KopacovaStanislav RejchrtTomas DoudaVit SestakLadislav DoudaJana Zdarova Karasova

Published in: PloS one (2020)

Both single and repeated doses of memantine increased DF. Severe gastric arrhythmia and long-lasting low power after repeated administration might explain possible gastric dysmotility side effects in the chronic use of memantine.

Keyphrases

early onset
atrial fibrillation