Time Trend and Association of Early-Onset Colorectal Cancer with Diverticular Disease in the United States: 2010-2021.

The incidence of EOCRC continuously increased from 2010 through 2021 in patients with and without diverticular disease and was 4-6 times higher among patients with diverticular disease. Patients with pre-existing diverticular disease were at a significantly increased risk for EOCRC.