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Plasma cell differentiation, antibody quality, and initial germinal center B cell population depend on glucose influx rate.

Shawna K BrookensSung Hoon ChoYeeun PaikKaylor MeyerAriel L RaybuckChloe ParkDalton L GreenwoodJeffrey C RathmellMark R Boothby
Published in: bioRxiv : the preprint server for biology (2023)
Glucose influx is critical for GC homeostasis, affinity maturation and the generation of Ab-secreting cells.Plasma cell development uses the Pentose Phosphate Pathway, and hexose sugars maintain redox homeostasis.PCs can develop and achieve robust Ab secretion in the absence of glucose using a combination of hexose alternatives.
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