3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.

Bao Khanh TrangMatthew C PahlJames A PippinChun SuSheridan H LittletonPrabhat SharmaNikhil N KulkarniLouis R GhanemNatalie A TerryJoan M O'BrienYadav WagleyKurt D HankensonAshley JermusykJason W HoskinsLaufey T AmundadottirMai XuKevin M BrownStewart A AndersonWenli YangPaul M TitchenellPatrick SealeLaura CookMegan K LevingsBabette S ZemelAlessandra ChesiAndrew D WellsStruan F A Grant

Published in: medRxiv : the preprint server for health sciences (2023)

We gain a systemic view of childhood obesity genomics by leveraging 3D techniques that implicate regulatory regions harboring causal variants, providing insights into the disease pathogenesis across different cellular systems.

Keyphrases

single cell
copy number
genome wide
cell therapy
transcription factor
dna methylation
stem cells
gene expression