Long-term outcomes with reduced-dose whole-brain radiotherapy and a stereotactic radiosurgery boost for primary central nervous system lymphoma.
Bronwen E ForemanTrey C MullikinScott R FloydChris R KelseyMallika P PatelKatherine B PetersJohn P KirkpatrickZachary J ReitmanEugene J VaiosPublished in: Neuro-oncology advances (2023)
The combination of rd-WBRT with an SRS boost appears well-tolerated with durable intracranial control. This approach may represent a treatment option for select patients, such as those with progressive or refractory disease. Further prospective studies are needed to validate these findings and determine whether this approach could be incorporated into consolidation strategies.
Keyphrases
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- early stage
- radiation therapy
- peritoneal dialysis
- diffuse large b cell lymphoma
- prognostic factors
- locally advanced
- white matter
- squamous cell carcinoma
- radiation induced
- resting state
- patient reported outcomes
- case control
- functional connectivity
- smoking cessation
- optic nerve