Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via PGE2-mediated ADAM-17 signaling in testosterone-induced benign prostatic hyperplasia.
Mohammed E Abo-El FetohMaha M Abdel-FattahWafaa R MohamedLaila A A RamadanHassan AfifyPublished in: Inflammopharmacology (2022)
COX-2 stimulates the ERK1/2 pathway via PGE2-ADAM-17-catalyzed shedding of TGF-α in testosterone-induced BPH. The results indicate a functional correlation between inflammation and hyperplasia in BPH.
Keyphrases
- benign prostatic hyperplasia
- lower urinary tract symptoms
- high glucose
- signaling pathway
- cell proliferation
- small cell lung cancer
- replacement therapy
- oxidative stress
- drug induced
- epidermal growth factor receptor
- endothelial cells
- nitric oxide
- epithelial mesenchymal transition
- nitric oxide synthase
- smoking cessation