P2Y2R and Cyst Growth in Polycystic Kidney Disease.

Andre KrausKathrin SkoczynskiMartin Brötsch Nicolai Burzlaff Jens Leipziger Mario Schiffer Frederick Pfister Bjoern Buchholz

Published in: Journal of the American Society of Nephrology : JASN (2024)

P2Y2R was significantly expressed in human and mouse polycystic kidneys. Deletion and antagonism of P2Y2R reduced cyst enlargement in an ADPKD mouse model.

Keyphrases

polycystic kidney disease
mouse model
endothelial cells
induced pluripotent stem cells