Antioxidant glutathione inhibits inflammation in synovial fibroblasts via PTEN/PI3K/AKT pathway: An in vitro study.

Published in: Archives of rheumatology (2021)

These findings suggest that GSH can act as an inflammatory suppressor by downregulating the PTEN/PI3K/AKT pathway in MH7A cells. These data indicated a novel function of GSH for improving the inflammation of RA SFs and may help to alleviate the pathological process of RA.

Keyphrases

oxidative stress
induced apoptosis
pi k akt
rheumatoid arthritis
cell cycle arrest
cell proliferation
fluorescent probe
disease activity
ankylosing spondylitis
signaling pathway
endoplasmic reticulum stress
systemic lupus erythematosus
cell death
extracellular matrix
deep learning
systemic sclerosis