Nickel-Catalyzed Desymmetrizing Cyclization of 1,6-Dienes to Construct Quaternary Stereocenters.

Tian-Yuan ZhaoKe LiLiang-Liang YangShou-Fei Zhu Qi-Lin Zhou

Published in: Organic letters (2021)

A highly enantioselective and diastereoselective nickel-catalyzed desymmetrizing cyclization of 1,6-dienes was developed by using chiral spiro phosphoramidite ligands. The reaction provides a new atom- and step-economical approach to chiral spiro lactones and analogues bearing a quaternary stereocenter.

Keyphrases

room temperature
ionic liquid
capillary electrophoresis
reduced graphene oxide
oxide nanoparticles
carbon nanotubes
metal organic framework
molecular dynamics
molecular docking
electron transfer
gold nanoparticles
molecular dynamics simulations