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Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells.

Nikolaos E EfstathiouGiannis A MoustafaDaniel E MaidanaEleni K KonstantinouShoji NotomiPaulo R T BarbisanConstantine D GeorgakopoulosJoan W MillerDemetrios G Vavvas
Published in: PloS one (2020)
Our results suggest that acadesine suppresses TNF-α induced C3, likely through an AMPK-independent pathway, and could have potential use in complement over activation diseases.
Keyphrases
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