Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Healing in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Factor- (HIF-) 1 Signalling.

Shuo QiuYachao JiaYunchu SunPei HanJia Xu Gen Wen Yi-Min Chai

Published in: Journal of diabetes research (2019)

Taken together, VH298 activated the HIF-1 signalling pathway by stabilizing both HIF-1α and hydroxy-HIF-1α. VH298 enhanced rFb functions, promoted hUVEC angiogenesis, and accelerated wound healing in the rat model mimicking diabetes mellitus.

Keyphrases

wound healing
endothelial cells
high glucose
diabetic rats
signaling pathway
high fat diet
oxidative stress
vascular endothelial growth factor
metabolic syndrome
adipose tissue
skeletal muscle
insulin resistance
binding protein
protein protein