Amyloid-independent atrophy patterns predict time to progression to dementia in mild cognitive impairment.
Mara Ten KateFrederik BarkhofPieter Jelle VisserCharlotte E TeunissenPhilip ScheltensWiesje M van der FlierBetty M TijmsPublished in: Alzheimer's research & therapy (2017)
In subjects with MCI, both abnormal amyloid CSF and decreased gray matter volume were associated with future progression to dementia. The spatial pattern of decreased gray matter volume associated with progression to dementia was consistent for amyloid-positive and amyloid-negative subjects.