Autofluorescence Imaging Reflects the Nuclear Enlargement of Tumor Cells as well as the Cell Proliferation Ability and Aberrant Status of the p53, Ki-67, and p16 Genes in Colon Neoplasms.
Kentaro MoriichiMikihiro FujiyaYu KobayashiYuki MurakamiTakuya IwamaTakehito KunogiTakahiro SasakiMasami IjiriKeitaro TakahashiKazuyuki TanakaAki SakataniKatsuyoshi AndoYoshiki NomuraNobuhiro UenoShin KashimaKatsuya IkutaHiroki TanabeYusuke MizukamiYusuke SaitohToshikatsu OkumuraPublished in: Molecules (Basel, Switzerland) (2019)
AFI reflects the nuclear enlargement of tumor cells, the cell proliferation ability, and the altered status of cell proliferation-related genes, indicating that AFI is a useful and practical method for predicting the dysplastic grade of tumor cells and cell proliferation.