ALKBH5-mediated m 6 A demethylation of TIRAP mRNA promotes radiation-induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma.

Yuhan ChenPeitao ZhouYixun DengXinni CaiMingrui SunYining SunDehua Wu

Published in: Clinical and translational medicine (2023)

Collectively, irradiation up-regulates ALKBH5 in HSC to mediate monocyte recruitment and M2 polarisation and form positive feedback to promote RILF and reduce HCC radiosensitivity. The dual roles of ALKBH5 as a microenvironmental regulator and radiosensitisation target provide new ideas for RILF prevention and radiosensitisation of HCC.

Keyphrases

radiation induced
liver fibrosis
radiation therapy
dendritic cells
transcription factor
endothelial cells
binding protein