Heterogeneity of small duct- and large duct-type intrahepatic cholangiocarcinoma.

Maximilian N KinzlerFalko SchulzeJan JerochChristina SchmittSilvana EbnerSteffen GretserJulia BeinFabian FinkelmeierJörg TrojanStefan ZeuzemAndreas A SchnitzbauerMelanie C DemesHenning ReisPeter J WildDirk Walter

Published in: Histopathology (2024)

A marked portion of patients with iCCA exhibits both SD- and LD-iCCA in different tumour regions. In case of the presence of histopathological heterogeneity, mutational profiling should be considered to avoid missing therapeutically relevant genetic alterations.

Keyphrases

single cell
genome wide
copy number