Confounding factors of Alzheimer's disease plasma biomarkers and their impact on clinical performance.

Alexa Pichet BinetteShorena JanelidzeNicholas CullenJeffrey L DageRandall J BatemanHenrik ZetterbergKaj BlennowErik StomrudNiklas Mattsson-CarlgrenOskar Hansson

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)

Creatinine and body mass index (BMI) are related to certain plasma biomarker levels. Adjusting for creatinine and BMI has minor influence on plasma-cerebrospinal fluid (CSF) associations. Adjusting for creatinine and BMI has minor influence on prediction of dementia using plasma biomarkers.

Keyphrases

body mass index
cerebrospinal fluid
weight gain
uric acid
mild cognitive impairment
cognitive decline
cognitive impairment