A two-photon fluorescent probe for sensitive detection and imaging of γ-glutamyl transpeptidase.

Ruijin Huo Xiuli Zheng Weimin LiuLiping ZhangJiasheng WuFan LiWenjun Zhang Chun-Sing Lee Pengfei Wang

Published in: Chemical communications (Cambridge, England) (2021)

A GGT-activated two-photon fluorescent probe (4F-2CN-GSH) was developed based on a cascade reaction. 4F-2CN-GSH could selectivily detect GGT with low detection limit and distinguish ovarian cancer cells from normal cells using both one-photon and two-photon fluorescence imaging.

Keyphrases

fluorescent probe
living cells
fluorescence imaging
sensitive detection
loop mediated isothermal amplification
induced apoptosis
lymph node metastasis
quantum dots
photodynamic therapy
high resolution
single molecule
cell cycle arrest
mass spectrometry
signaling pathway
cell proliferation