Butyrate acts as a positive allosteric modulator of the 5-HT transporter to decrease availability of 5-HT in the ileum.

Jieling CaiJamie CheungSamson W M CheungKarie T C ChinRicky W K LeungRonald S T LamRakesh SharmaJensen H C YiuConnie Wai Hong Woo

Published in: British journal of pharmacology (2023)

Short-term HFD may be beneficial for alleviating gastrointestinal reactions by increasing butyrate to suppress local 5-HT levels and providing energy to cancer patients given radiation therapy.

Keyphrases

radiation therapy
small molecule
high fat diet
squamous cell carcinoma
radiation induced