Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis.

Sandra VieiraQiyong GongCristina ScarpazzaSu LuiXiaoqi HuangBenedicto Crespo-FacorroDiana Tordesillas-GutierrezVíctor Ortiz-García de la FozEsther Setien-SueroFloor ScheepersNeeltje E M van HarenRené KahnTiago Reis MarquesSimone CiufoliniMarta Di FortiRobin M MurrayAnthony DavidPaola DazzanPhilip McGuireAndrea Mechelli

Published in: Psychological medicine (2019)

This study identified a consistent pattern of fronto-temporal, insular and occipital abnormalities in five independent FEP samples; furthermore, the extent of these alterations is dependent on the severity of symptoms and duration of illness. This provides evidence for reliable neuroanatomical alternations in FEP, expressed above and beyond site-related differences in anti-psychotic medication, scanning parameters and recruitment criteria.

Keyphrases

emergency department
adverse drug
bipolar disorder
healthcare
high resolution
sleep quality
electronic health record
drug induced
data analysis