Statins, diabetes mellitus and prognosis of amyotrophic lateral sclerosis: data from 501 patients of a population-based registry in southwest Germany.
J SchumacherR S PeterGabriele NagelD RothenbacherA RosenbohmA C LudolphJohannes Dorstnull nullPublished in: European journal of neurology (2020)
This study supports the view that statin use is not associated with overall survival of ALS patients, suggesting that statins are not harmful and should not be discontinued in ALS. Furthermore, the delayed onset of ALS in patients with DM may mirror the potentially protective metabolic profile associated with type 2 DM. Consistently, this study provides further evidence that high body mass index is a positive prognostic factor in ALS.
Keyphrases
- amyotrophic lateral sclerosis
- prognostic factors
- end stage renal disease
- body mass index
- newly diagnosed
- cardiovascular disease
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- coronary artery disease
- type diabetes
- machine learning
- skeletal muscle
- electronic health record
- insulin resistance
- artificial intelligence