Role of Kir4.1/Kir5.1 in mediating Angiotensin-II (Ang-II)-induced stimulation of thiazide-sensitive Na-Cl cotransporter.

Xin-Peng DuanXin-Xin MengYu XiaoCheng-Biao ZhangRuimin GuDao-Hong Lin Wen-Hui Wang

Published in: bioRxiv : the preprint server for biology (2024)

Short-term Ang-II induced stimulation of pWNK4, pSPAK and pNCC depends on Kir4.1/Kir5.1 activity. However, long-term Ang-II is able to directly stimulate pWNK4, pSPAK and pNCC by a Kir4.1/Kir5.1 independent mechanism.

Keyphrases

angiotensin ii
angiotensin converting enzyme
vascular smooth muscle cells
high glucose
diabetic rats
endothelial cells
oxidative stress