A Genomically and Clinically Annotated Patient-Derived Xenograft Resource for Preclinical Research in Non-Small Cell Lung Cancer.
Xing Yi WooAnuj SrivastavaPhilip C MackJoel H GraberBrian J SandersonMichael W LloydMandy ChenSergii DomanskyiRegina Frances Gandour-EdwardsRebekah A TsaiJames KeckMingshan ChengMargaret BundyEmily L JocoyJonathan W RiessWilliam HollandStephen C GrubbJames G PetersonGrace A StaffordCarolyn PaisieSteven B NeuhauserR Krishna Murthy KaruturiJoshy GeorgeAllen K SimonsMargaret ChavareeClifford G TepperNeal C GoodwinSusan D AirhartPrimo N LaraThomas H OpenshawEdison T LiuDavid R GandaraCarol J BultPublished in: Cancer research (2022)
Patient-derived xenografts of lung cancer retain key features observed in the originating patient tumors and show expected responses to treatment with standard-of-care agents, providing experimentally tractable and reproducible models for preclinical investigations.