DNA-Damaging Therapies in Patients With Prostate Cancer and Pathogenic Alterations in Homologous Recombination Repair Genes.
Laura S GrahamNicholas C HendersonOlesia KelleziClara HwangPedro C BarataMehmet Asim BilenDeepak KilariMichael PierroBicky ThapaAbhishek TripathiGeorge MoMatthew Kyle LabriolaJoseph J ParkShoshana RothsteinRohan GarjeVadim S KoshkinVaibhav G PatelTanya Barauskas DorffAndrew J ArmstrongRana R McKayAjjai AlvaMichael Thomas SchweizerPublished in: JCO precision oncology (2024)
-mutated PC had significantly improved outcomes to PARPi but not platinum chemotherapy compared with those with HRR mutations without direct BRCA complex interaction.