CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease.
Aurore DelvenneJohan GobomSuzanne E SchindlerMara Ten KateLianne M ReusValerija DobricicBetty M TijmsTammie L S BenzingerCarlos CruchagaCharlotte E TeunissenInez RamakersPablo Martinez-LageMikel TaintaRik VandenbergheJolien SchaeverbekeSebastiaan EngelborghsEllen De RoeckJulius PoppGwendoline PeyratoutMagda TsolakiYvonne Freund-LeviSimon LovestoneJohannes StrefferFrederik BarkhofLars BertramKaj BlennowHenrik ZetterbergPieter Jelle VisserStephanie J B VosPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
In Alzheimer's disease, neurogranin (Ng)+, neurofilament light (NfL)+, and hippocampal volume (HCV)+ showed differential protein expression in cerebrospinal fluid. Ng+ and NfL+ were associated with neuroplasticity, although in opposite directions. HCV+ showed few proteomic changes, related to oxidative stress. Neurodegeneration (N) markers may differentially refine disease staging beyond amyloid and tau. Ng might not be an optimal N marker, as it relates more closely to tau.