Analyses of PD-L1 and Inflammatory Gene Expression Association with Efficacy of Nivolumab ± Ipilimumab in Gastric Cancer/Gastroesophageal Junction Cancer.
Ming LeiNathan O SiemersDimple PandyaHan ChangTeresa SanchezChristopher HarbisonPeter M SzaboYelena JanjigianPatrick A OttPadmanee SharmaJohanna BendellThomas R Jeffry EvansFilippo de BraudIan ChauZachary BoydPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
This study suggests a greater association of PD-L1 expression by CPS with NIVO ± IPI efficacy compared with % TC PD-L1 expression in patients with GC/GEJC. Inflammatory signatures were also associated with NIVO ± IPI response, warranting further investigation.See related commentary by Moutafi and Rimm, p. 3812.