D-dopachrome tautomerase activates COX2/PGE2 pathway of astrocytes to mediate inflammation following spinal cord injury.

Huiyuan JiYuxin ZhangChen ChenHui LiBingqiang HeTing YangChunshuai SunHuifei HaoXingyuan ZhangYingjie WangYue ZhouZhenjie ZhuYuming HuAihong LiAisong GuoYongjun Wang

Published in: Journal of neuroinflammation (2021)

Collectively, these data reveal a novel inflammatory activator of astrocytes following spinal cord injury, which might be beneficial for the development of anti-inflammation drug in neuropathological CNS.

Keyphrases

spinal cord injury
oxidative stress
spinal cord
neuropathic pain
electronic health record
blood brain barrier
genome wide
nuclear factor
big data
single cell
emergency department
deep learning
drug induced
adverse drug