Effect of injectable progestin-only contraceptives, depot medroxyprogesterone acetate and norethisterone enanthate, on cytokine production during T-cell activation.
Allen T MatubuSharon L HillierLeslie A MeynKevin A StonerFelix MhlangaMike MbizvoAaron MarambaZvavahera M ChirenjeSharon L AchillesPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2021)
In vivo exposure of CD4+ and CD8+ T cells to typical pharmacologic concentrations of DMPA does not cause broad suppression to stimuli; however, depletion of specific cytokine-producing T cells may occur after prolonged DMPA use.
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