Two pairs of 2-pyrone enantiomers and a benzophenone analogue from the endophytic fungus Penicillium egyptiacum .
Xiao-Ming ZhengYa-Long ZhangHong YangJian BaiYou-Cai HuPublished in: Journal of Asian natural products research (2023)
Four new 2-pyrone derivatives, two pairs of enantiomers, (±)-egypyrone A [(±)- 1 ] and (±)-egypyrone B [(±)- 2 ], together with a new benzophenone analogue, orbiophenone B ( 3 ), were isolated from the endophytic fungus Penicillium egyptiacum . The enantiomeric mixtures (±)- 1 and (±)- 2 were separated through chiral HPLC, respectively. Their structures were elucidated by extensive analysis of spectroscopic data and the absolute configuration was determined by comparing the optical rotation of structurally similar molecule. Subsequently, the cytotoxic activities of (±)- 1 , (±)- 2 , and 3 against the U87 cell line were tested and no activity was observed at a concentration of 10 µ M.
Keyphrases
- capillary electrophoresis
- mass spectrometry
- high resolution
- ms ms
- high performance liquid chromatography
- ionic liquid
- molecular docking
- simultaneous determination
- electronic health record
- liquid chromatography
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- machine learning
- structure activity relationship
- deep learning
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