Analysis of the finasteride treatment and its withdrawal in the rat hypothalamus and hippocampus at whole-transcriptome level.
S GiattiL CioffiS DiviccaroR PiazzaRoberto Cosimo MelcangiPublished in: Journal of endocrinological investigation (2024)
Some of the genes reported to be differentially expressed (i.e., TTR, DIO2, CLDN1, CLDN2, SLC4A5, KCNE2, CROT, HCRT, MARCKSL1, VGF, IRF2BPL) and GSEA, suggest a potential link with specific side effects previously observed in patients and in the animal model, such as depression, anxiety, disturbance in memory and attention, and sleep disturbance. These data may provide an important background for future experiments aimed at confirming the pathological role of these genes.
Keyphrases
- genome wide
- sleep quality
- end stage renal disease
- working memory
- ejection fraction
- newly diagnosed
- chronic kidney disease
- gene expression
- oxidative stress
- depressive symptoms
- peritoneal dialysis
- machine learning
- electronic health record
- immune response
- bioinformatics analysis
- current status
- big data
- deep learning
- risk assessment
- human health
- data analysis
- genome wide analysis
- artificial intelligence