Genomic and transcriptomic characteristics of metastatic thyroid cancers with exceptional responses to radioactive iodine therapy.
Laura BoucaiMahesh SaqcenaFengshen KuoRavinder K GrewalNicholas D SocciJeffrey A KnaufGnana P KrishnamoorthyMabel RyderAlan L HoRonald A GhosseinLuc G T MorrisVenkatraman E SeshanJames A FaginPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
ER tumors have a lower MAPK output and higher TDS than NR, whereas NR have a high frequency of BRAFV600E and 1q-gain. Molecular profiling of thyroid cancers and further functional validation of the key findings discriminating ER from NR may help predict response to RAI therapy.